The story of the creation of the so-called vitamin V has not done without errors. Actually errors led to perfect discoveries.
You should remember Columbus, who thought that he was going to Asia, or a recent example of a specialist from the company of “ZM” who developed a glue that had a very weak properties, this led to the writing paper that you can glue anywhere on the same fridge and no trace remains.
Such mistakes often happened in medicine, a lot of drugs appeared in such a way… But there were useful errors such as a cure for smallpox, penicillin, and so on.
In fact the very creation of Viagra is in the row of accidents. Although its value on medicine was enormous.
Initially, Dr. Ian Osterloh together with his team developed the cure for angina – heart disease which is caused by excessively low supply of oxygen to the heart.
The active substance was Sildenafil citrate. Scientists assumed that the drug would suppress the activity of the enzyme phosphodiesterase of the fourth type (PDE 4), which would allow significantly expanding the arteries and improving blood flow.
This should help to relieve pain in the heart area. However, a series of clinical trials showed that Viagra Sildenafil citrate didn’t have analgesic effect. In December ‘ 92, the company stopped funding and started folding studies.
There was an amazing fact: many men, who took part in the study, refused to return the test samples of pills in the lab with the risk to life. The staff of Pfizer decided to find out the cause of this behavior.
They were surprised when they found that a side effect of the drug was able to increase erection of men.
The most interesting fact that all study participants signed the document, which clearly stated that they were obliged to inform the company of all of even the most minor side effects like itching.
There were complains on headache, nausea, diarrhea, high blood pressure, but there were no data on erection. However, when Pfizer started the trial it became clear that every 2nd man had increased the erection while taking the test drug.
And it was a breakthrough, Viagra sildenafil citrate didn’t help with the pain with the heart, but it also allowed us to immediately understand that it didn’t affect heart blood vessels, which were supposed to expand and increase blood flow to the heart.
But the drug acted on blood vessels of the penis. However, local scientists wondered that if the PDE 4, which is generally not as associated with the enzyme in the penis, had such an effect, what the result will be from PDE 5, which inhibits the influx of nitric oxide, a substance that is responsible for erection in our body? It binds much faster. There were immediately conducted clinical trials, which were simply amazing and pleasing, because cheap Viagra received a new birth from the drug for the treatment of heart problems to drug for the treatment of erectile dysfunction.
Are there any contraindications for use with other medications?
Generic Viagra can be used with almost any medicines, including drugs for diabetes, blood thinners, antacids and aspirin. However, cheap Viagra is contraindicated to patients who use drugs containing nitrates used in the treatment of heart disease. Their joint use can cause a decrease in blood pressure.
Are there any age restrictions ?
Viagra was not tested on men under the age of 18 years. During clinical tests, the drug was recognized as safe for men under the age of 85 years.
How should you order Viagra without prescription?
The drug is taken for 0.5-2 hours prior to expected sexual contact. The maximum level of the active substance Sildenafil citrate in the blood occurs approximately 60 minutes after ingestion.
Will you get spontaneous erection after you buy Viagra online?
No, you won’t. A huge plus of generic Viagra is that it works only with sexual arousal.
What is the optimal frequency of use of the drug?
You should use the product not more than 1 time a day.
What dose should you use? What doses is the drug released in?
Viagra is produced in tablets containing from 25 to 100 mg of active substance. You should buy Viagra online and use the minimum dose when you notice a positive effect. The higher the dose is, the greater the intensity of side effects will be. It is recommended to begin the treatment with doses of 50 mg and then, it can be changed according to your feelings.